CLINICAL TRIALS AND OBSERVATIONS Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias
نویسندگان
چکیده
1Division of Hematologic Malignancies, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; 2Division of Hematology, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD; 3Division of Chemical Therapeutics, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD; and 4Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD
منابع مشابه
Phase I and Pharmacokinetic Study of Flavopiridol followed by1-B-D-Arabinofuranosylcytosine andMitoxantrone in Relapsed and RefractoryAdult Acute Leukemias
Purpose: The serine/threonine kinase inhibitor flavopiridol targets multiple cyclin-dependent kinases, induces checkpoint arrest, and interrupts transcriptional elongation.We designed aphase I clinical trial using a timed sequential therapy approachwhere flavopiridol was given for the dual purpose of initial cytoreduction and enhancing cell cycle progression of the remaining leukemia cell cohor...
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